{"id":503,"date":"2018-05-02T12:08:54","date_gmt":"2018-05-02T12:08:54","guid":{"rendered":"https:\/\/protsci-us2b.univ-nantes.fr\/mobpdb\/?page_id=503"},"modified":"2023-04-08T14:08:07","modified_gmt":"2023-04-08T14:08:07","slug":"anopheles-gambiae","status":"publish","type":"page","link":"https:\/\/protsci-us2b.univ-nantes.fr\/mobpdb\/?page_id=503","title":{"rendered":"Anopheles gambiae"},"content":{"rendered":"<p><a href=\"https:\/\/i0.wp.com\/protsci-us2b.univ-nantes.fr\/mobpdb\/wp-content\/uploads\/2015\/10\/A.gamb_mali_852cc.jpg?ssl=1\"><img data-recalc-dims=\"1\" loading=\"lazy\" decoding=\"async\" class=\"alignright size-medium wp-image-190\" src=\"https:\/\/i0.wp.com\/protsci-us2b.univ-nantes.fr\/mobpdb\/wp-content\/uploads\/2015\/10\/A.gamb_mali_852cc.jpg?resize=120%2C180&#038;ssl=1\" alt=\"A.gamb_mali_852cc\" width=\"120\" height=\"180\"><\/a>The most widespread mosquito of the genus <em>Anopheles<\/em> in sub-Saharan Africa is <em>Anopheles<\/em><em> gambiae<\/em>. This species is the main vector for transmitting malaria parasite, <em>Plasmodium falciparum<\/em>. The general coloration of this species is yellowish brown to brown with the last segment of the body normally all dark. Its whole genome was the first amongst mosquitoes to be sequenced in 2002.<\/p>\n<p><strong>Statistics of OBPs from <em>Anopheles gambiae<\/em>:<\/strong><\/p>\n<table style=\"height: 34px;\" border=\"\u00bb1\u2033\" width=\"600\" cellspacing=\"\u00bb0\u2033\" cellpadding=\"\u00bb0\u2033\">\n<tbody>\n<tr style=\"text-align: center;\">\n<td>&nbsp;<\/td>\n<td>\n<form action=\"\/cgi-bin\/mobpdb\/resultat_sql.cgi\" method=\"post\"><button name=\"sql_query\" type=\"submit\" value=\"select * from proteins_v3 where Class = 'Classic' and Name like 'agamobp%'\">Classic<\/button><\/form>\n<\/td>\n<td>\n<form action=\"\/cgi-bin\/mobpdb\/resultat_sql.cgi\" method=\"post\"><button name=\"sql_query\" type=\"submit\" value=\"select * from proteins_v3 where Class = 'PlusC' and Name like 'agamobp%'\">PlusC<\/button><\/form>\n<\/td>\n<td>\n<form action=\"\/cgi-bin\/mobpdb\/resultat_sql.cgi\" method=\"post\"><button name=\"sql_query\" type=\"submit\" value=\"select * from proteins_v3 where Class = 'Two-domains' and Name like 'agamobp%'\">Two-domains*<\/button><\/form>\n<\/td>\n<td>Total<\/td>\n<\/tr>\n<tr style=\"text-align: center;\">\n<td>Number of OBPs<\/td>\n<td style=\"text-align: center;\">30<\/td>\n<td style=\"text-align: center;\">23<\/td>\n<td style=\"text-align: center;\">16<\/td>\n<td style=\"text-align: center;\">69<\/td>\n<\/tr>\n<tr>\n<td><a href=\"https:\/\/protsci-us2b.univ-nantes.fr\/mobpdb\/?page_id=409\" target=\"_blank\" rel=\"noopener\">N\u00b0 with atomic structures (in PDB)<\/a><\/td>\n<td style=\"text-align: center;\">5<\/td>\n<td style=\"text-align: center;\">1<\/td>\n<td>&nbsp;<\/td>\n<td style=\"text-align: center;\">6<\/td>\n<\/tr>\n<tr>\n<td>3D models<\/td>\n<td style=\"text-align: center;\">\n<form action=\"\/cgi-bin\/mobpdb\/resultat_sql.cgi\" method=\"post\"><button name=\"sql_query\" type=\"submit\" value=\"select ID, Name, Uniprot, Class, Cluster from proteins_v3 where Class = 'Classic' and Name like 'agamobp%'\">30<\/button><\/form>\n<\/td>\n<td style=\"text-align: center;\">&#8211;<\/td>\n<td style=\"text-align: center;\">&#8211;<\/td>\n<td style=\"text-align: center;\">30<\/td>\n<\/tr>\n<tr>\n<td>Docking results**<\/td>\n<td style=\"text-align: center;\">30 x 126 = 3780<\/td>\n<td style=\"text-align: center;\">&#8211;<\/td>\n<td style=\"text-align: center;\">&#8211;<\/td>\n<td style=\"text-align: center;\">3780<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><span style=\"font-size: xx-small;\">*(also known as <em>duplex<\/em> or <em>atypical<\/em>)<br \/>\n**(molecular docking was performed on 126 odorants that are known repellants and attractants for mosquitoes)<\/span><\/p>\n<table width=\"100%\">\n<tbody>\n<tr>\n<td><strong>Search the <span style=\"color: #3366ff;\">genomic<\/span> database for all OBP genes from <em>Anopheles gambiae<\/em><\/strong>&nbsp;&nbsp;<\/p>\n<form action=\"\/cgi-bin\/mobpdb\/motclef.cgi\" method=\"post\"><button name=\"smalldialogue\" type=\"submit\" value=\"AGAP\">Browse genomic data<\/button><\/form>\n<\/td>\n<\/tr>\n<tr>\n<td><strong>Modelled structures of <em>Classic<\/em> OBP from <em>Anopheles gambiae<\/em><\/strong>&nbsp;&nbsp;<\/p>\n<form action=\"\/cgi-bin\/mobpdb\/resultat_sql.cgi\" method=\"post\"><button name=\"sql_query\" type=\"submit\" value=\"select ID, Name, Uniprot, Class, Cluster from proteins_v3 where Class = 'Classic' and Name like 'agamobp%'\">Browse models<\/button><\/form>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>Download of fasta sequences of all OBPs from <em>Anopheles gambiae <\/em>:<br \/>\n<a href=\"https:\/\/protsci-us2b.univ-nantes.fr\/mobpdb\/wp-content\/uploads\/2015\/10\/Anopheles_gambiae.txt\"><img data-recalc-dims=\"1\" loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-315\" src=\"https:\/\/i0.wp.com\/protsci-us2b.univ-nantes.fr\/mobpdb\/wp-content\/uploads\/2015\/10\/download-btn.png?resize=75%2C26&#038;ssl=1\" alt=\"download-btn\" width=\"75\" height=\"26\"><\/a><\/p>\n<p><strong>Please cite<\/strong><br \/>\n<span style=\"font-size: xx-small;\"><a href=\"http:\/\/gbe.oxfordjournals.org\/content\/5\/1\/163.long\" target=\"_blank\" rel=\"noopener\">Manoharan M, Ng Fuk Chong M, Va\u00eftinadapoul\u00e9 A, Frumence E, Sowdhamini R, Offmann B. Comparative genomics of odorant binding proteins in Anopheles gambiae, Aedes aegypti, and Culex quinquefasciatus. <em>Genome Biol Evol.<\/em> 2013;<strong>5<\/strong>(1):163-80.<\/a><br \/>\n<\/span><\/p>\n<p><strong>Other bibliographic reference(s):<\/strong><\/p>\n<ol>\n<li>Vogt, R.G., Rogers, M.E., Franco, M.D., and Sun, M. 2002. A comparative study of odorant binding protein genes: differential expression of the PBP1-GOBP2 gene cluster in Manduca sexta (Lepidoptera) and the organization of OBP genes in Drosophila melanogaster (Diptera). The&nbsp; Journal of experimental biology 205: 719-744.<\/li>\n<li>Xu, P.X., Zwiebel, L.J., and Smith, D.P. 2003. Identification of a distinct family of genes encoding atypical odorant-binding proteins in the malaria vector mosquito, Anopheles gambiae. Insect molecular biology 12: 549-560.<\/li>\n<li>Zhou, J.J., Huang, W., Zhang, G.A., Pickett, J.A., and Field, L.M. 2004. &#8220;Plus-C&#8221; odorant-binding protein genes in two Drosophila species and the malaria mosquito Anopheles gambiae. Gene 327: 117-129.<\/li>\n<li>Vieira, F.G. and Rozas, J. 2011. Comparative Genomics of the Odorant-Binding and Chemosensory Protein Gene Families across the Arthropoda: Origin and Evolutionary History of the Chemosensory System. Genome biology and evolution 3: 476-490.<\/li>\n<\/ol>\n<p><!--\n\n\n\n<form action=\"\/cgi-bin\/mobpdb\/motclef3.cgi\" method=\"post\">  \n<textarea id =\"smallrecherche\" rows=\"1\" cols=\"10\" name=\"smalldialogue\" style=\"font-family : courier\" >AGAMOBP<\/textarea> <input type=\"submit\" value=\"Submit request\" \/>\n<\/form>\n\n\n\n--><\/p>\n","protected":false},"excerpt":{"rendered":"<p>The most widespread mosquito of the genus Anopheles in sub-Saharan Africa is Anopheles gambiae. This species is the main vector for transmitting malaria parasite, Plasmodium falciparum. The general coloration of this species is yellowish brown to brown with the last segment of the body normally all dark. Its whole genome was the first amongst mosquitoes [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":0,"parent":9,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"page-without-sidebar.php","meta":{"footnotes":""},"class_list":["post-503","page","type-page","status-publish","hentry"],"jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/protsci-us2b.univ-nantes.fr\/mobpdb\/index.php?rest_route=\/wp\/v2\/pages\/503","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/protsci-us2b.univ-nantes.fr\/mobpdb\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/protsci-us2b.univ-nantes.fr\/mobpdb\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/protsci-us2b.univ-nantes.fr\/mobpdb\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/protsci-us2b.univ-nantes.fr\/mobpdb\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=503"}],"version-history":[{"count":11,"href":"https:\/\/protsci-us2b.univ-nantes.fr\/mobpdb\/index.php?rest_route=\/wp\/v2\/pages\/503\/revisions"}],"predecessor-version":[{"id":1199,"href":"https:\/\/protsci-us2b.univ-nantes.fr\/mobpdb\/index.php?rest_route=\/wp\/v2\/pages\/503\/revisions\/1199"}],"up":[{"embeddable":true,"href":"https:\/\/protsci-us2b.univ-nantes.fr\/mobpdb\/index.php?rest_route=\/wp\/v2\/pages\/9"}],"wp:attachment":[{"href":"https:\/\/protsci-us2b.univ-nantes.fr\/mobpdb\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=503"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}