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Mosquito OBP database (mOBPdb)
Welcome to the database for odorant binding proteins (OBP) for mosquitoes.
The molecular basis of the odorant perception of the mosquitoes is encoded by a series of proteins. One of the members considered very important in this process are the odorant binding proteins (OBPs) which are believed to aid in the transport of odorants and pheromones to the odorant receptors (ORs) and have emerged as novel targets for repellants.
Among the mosquito OBPs, we are currently reporting 69 OBPs in Anopheles gambiae, 111 OBPs in the Aedes aegypti and 109 OBPs in the Culex quinquefasciatus genomes.
There are 3 families of odorant binding proteins in mosquitoes :
- the Classic OBPs
- the PlusC OBPs
- the Two-domains also know as duplex and OBPs formerly know as the Atypical OBPs
The hallmark of OBPs are their conserved 6 cysteines that forms 3 disulphide bridges.However the number of cysteines and the disulphide connectivity patterns of the OBPs vary among the different subfamilies. Click here for a graphical illustration. A subgroup in the Classic OBPs called the MinusC OBPs and a subgroup in the two domain OBP subfamily called the matype2 do not have all the six conserved cysteines in their OBP domains. Atypical odorant binding proteins are in fact two-domain OBPs, where each domain is distantly related to the Classic OBPs.
We are providing in this database
- full genomic data (list of OBP genes, chromosomal or supercontig localization, sequence alignment data, phylogenetic data and orthologues).
- 3D structures for all Classic OBPs obtained through comparative modelling in the form of downloadable PDB files.
- functional characterization of all Classic OBPs screened against a large library of 126 odorants known to be repellents and attractants using molecular docking technique together with corresponding free energies of binding (FEB), Ki values (i.e Kd), size-independant ligand binding efficiencies values and PDB files of corresponding protein-odorant complexes.
Results for 3D modelling and subsequent ligand screening is not yet available for PlusC and Two-domains (duplex formerly know as atypical) OBPs. We are currently working to make them available soon.
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Contact details
Bernard Offmann (bernard.offmann ‘@’ univ-nantes.fr)
Developping team
Head: Bernard Offmann (Nantes Université, France), Sowdhamini Ramanathan (NCBS – TIFR, India)
Current students: Damien Rat, Julien Louet
Former students: Malini Manoharan, Matthieu Ng Fuk Cheong, Aurore Vaïtinadapoullé, Etienne Frumence, Olivier Cadet, Nicolas Belouin, Charlotte Berthelier, Amandine Lecerf Defer, Bavikha Mam, Surbhi Dhingra, Marine Averty, Nicolas Antunes
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