Anopheles gambiae
April 8th, 2023
The most widespread mosquito of the genus Anopheles in sub-Saharan Africa is Anopheles gambiae. This species is the main vector for transmitting malaria parasite, Plasmodium falciparum. The general coloration of this species is yellowish brown to brown with the last segment of the body normally all dark. Its whole genome was the first amongst mosquitoes to be sequenced in 2002.
Statistics of OBPs from Anopheles gambiae:
| Total | ||||
| Number of OBPs | 30 | 23 | 16 | 69 |
| N° with atomic structures (in PDB) | 5 | 1 | 6 | |
| 3D models | – | – | 30 | |
| Docking results** | 30 x 126 = 3780 | – | – | 3780 |
*(also known as duplex or atypical)
**(molecular docking was performed on 126 odorants that are known repellants and attractants for mosquitoes)
| Search the genomic database for all OBP genes from Anopheles gambiae |
| Modelled structures of Classic OBP from Anopheles gambiae |
Download of fasta sequences of all OBPs from Anopheles gambiae :
Other bibliographic reference(s):
- Vogt, R.G., Rogers, M.E., Franco, M.D., and Sun, M. 2002. A comparative study of odorant binding protein genes: differential expression of the PBP1-GOBP2 gene cluster in Manduca sexta (Lepidoptera) and the organization of OBP genes in Drosophila melanogaster (Diptera). The Journal of experimental biology 205: 719-744.
- Xu, P.X., Zwiebel, L.J., and Smith, D.P. 2003. Identification of a distinct family of genes encoding atypical odorant-binding proteins in the malaria vector mosquito, Anopheles gambiae. Insect molecular biology 12: 549-560.
- Zhou, J.J., Huang, W., Zhang, G.A., Pickett, J.A., and Field, L.M. 2004. “Plus-C” odorant-binding protein genes in two Drosophila species and the malaria mosquito Anopheles gambiae. Gene 327: 117-129.
- Vieira, F.G. and Rozas, J. 2011. Comparative Genomics of the Odorant-Binding and Chemosensory Protein Gene Families across the Arthropoda: Origin and Evolutionary History of the Chemosensory System. Genome biology and evolution 3: 476-490.