Anopheles sinensis

March 31st, 2023

Anopheles sinensis is a species of mosquito that transmits malaria as well as lymphatic filariasis. It is regarded as the most important vector of these human parasitic diseases in Southeast Asia [1][2]. It is the primary vector of vivax malaria (Plasmodium vivax) in many regions. In China it also transmits the filalarial parasite (Wuchereria bancrofti) [3], and arthropod roundworm (Romanomermis jingdeensis) [4]. In Japan it is also a vector of a roundworm Setaria digitata in sheep and goats [5][6]. Because of its similarity with other Anopheles, it is now considered a species complex comprising at least four species. Its genome was sequenced in 2014 [7].
(source & for more information : wikipedia)

Statistics of OBPs from Anopheles sinensis:





Total
Number of OBPs 20 18 12 1 51
N° with atomic structures (in PDB) NA NA NA
3D models NA NA NA NA
Docking results** NA NA NA NA

*(also known as duplex or atypical)
**(molecular docking was performed on 126 odorants that are known repellants and attractants for mosquitoes)
ND :undetermined
NA : Not Available

Search the genomic database for all OBP genes from Anopheles sinensis


Modelled structures of Classic OBP from Anopheles sinensis


Please cite
Manoharan M, Ng Fuk Chong M, Vaïtinadapoulé A, Frumence E, Sowdhamini R, Offmann B. Comparative genomics of odorant binding proteins in Anopheles gambiae, Aedes aegypti, and Culex quinquefasciatus. Genome Biol Evol. 2013;5(1):163-80.

Bibliographic references

  1. Ree, Han-Il (2005). “Studies on Anopheles sinensis, the vector species of vivax malaria in Korea”. The Korean Journal of Parasitology. 43 (3): 75–92. doi:10.3347/kjp.2005.43.3.75. PMC 2712014 Freely accessible. PMID 16192749.
  2. Chang, Xuelian; Zhong, Daibin; Fang, Qiang; Hartsel, Joshua; Zhou, Guofa; Shi, Linna; Fang, Fujin; Zhu, Changliang; Yan, Guiyun; Mutuku, Francis (2014). “Multiple Resistances and Complex Mechanisms of Anopheles sinensis Mosquito: A Major Obstacle to Mosquito-Borne Diseases Control and Elimination in China”. PLoS Neglected Tropical Diseases. 8 (5): e2889. doi:10.1371/journal.pntd.0002889. PMC 4031067 Freely accessible. PMID 24852174.
  3. Zhang, S; Cheng, F; Webber, R (1994). “A successful control programme for lymphatic filariasis in Hubei, China”. Transactions of the Royal Society of Tropical Medicine and Hygiene. 88 (5): 510–2. doi:10.1016/0035-9203(94)90140-6. PMID 7992323.
  4. Yang, XS; Fang, TZ; Chen, DH; Cai, GY; Li, MS; Geng, RG (1984). “Preliminary field trials of Romanomermis jingdeensis against Anopheles sinensis in the suburbs of Shanghai”. Chinese medical journal. 97 (8): 609–12. PMID 6440752.
  5. Zhao, Yonghua (1992). “Study on the life cycle of Setaria digitata”. Journal of Yunnan Agricultural University. 6 (2): 110–115. Archived from the original on 2014-08-08.
  6. Anderson, R.C. (2000). Nematode Parasites of Vertebrates Their Development and Transmission (2nd ed.). Wallingford: CAB International. p. 480. ISBN 978-0-8519-9786-5.
  7. Zhou, Dan; Zhang, Donghui; Ding, Guohui; Shi, Linna; Hou, Qing; Ye, Yuting; Xu, Yang; Zhou, Huayun; Xiong, Chunrong; Li, Shengdi; Yu, Jing; Hong, Shanchao; Yu, Xinyou; Zou, Ping; Chen, Chen; Chang, Xuelian; Wang, Weijie; Lv, Yuan; Sun, Yan; Ma, Lei; Shen, Bo; Zhu, Changliang (2014). “Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites”. BMC Genomics. 15 (1): 42. doi:10.1186/1471-2164-15-42. PMC 3901762  Freely accessible. PMID 24438588.

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